About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us atwww.abbvie.com. Follow @abbvie onLinkedIn,Facebook,Instagram,XandYouTube.

Key Responsibilities

• Synthesis, purification, and characterization of antibody oligonucleotide conjugates (AOCs) and antibody drug conjugates (ADCs) on mg to gram scale under minimal supervision.
• Design and executeengineered cysteine antibody conjugationworkflows
• Optimize reaction stoichiometry,linker chemistry, and reaction conditions to improvepeptide-to-antibody ratiosandproduct homogeneity.
• Development, optimization, and validation of conjugation protocols specifically for antibody oligonucleotide conjugates.
• Optimization and validation of formulation buffers for bioconjugates.
• Application and refinement of automated techniques for AOC/ADC synthesis and purification.
• Collaboration with cross-functional teams to advance AOC discovery programs from conceptualization to early development.
• Develop and optimize peptideantibody conjugation strategies
• Optimize reaction stoichiometry, linker chemistry, and reaction conditions to improve peptide-to-antibody ratios and product homogeneity.
• Investigate and mitigate sources of conjugation heterogeneity such as over-reduction, disulfide scrambling, hydrolysis, and aggregation.
• Apply diverse conjugation chemistries including thiol-reactive linkers, maleimide coupling, NHS ester chemistry, and bioorthogonal click chemistry (e.g., azidealkyne cycloaddition).
• Characterize conjugates using analytical techniques including SEC-HPLC, LC-MS (intact/reduced), RP-HPLC, and SDS-PAGE.
• Access external innovation to complement internal efforts

Qualifications

• Bachelors Degree or equivalent education and typically, 12 years of experience, Masters Degree or equivalent education and typically 10 years of experience, PhD and typically 4 years of experience.
• Expertise in the discovery, design, synthesis, and purification of Antibody Oligonucleotide Conjugates (AOC), including familiarity with associated chemistries and analytical methods.
• Hands-on experience with relevant analytical techniques such as HIC-HPLC, SEC, IEX, RP-HPLC, and capillary electrophoresis techniques (e.g., CE-SDS, icIEF).
• Proven problem-solving skills, motivation, enthusiasm, attention to detail, and the ability to thrive in a fast-paced, cross-disciplinary team environment.
• Superior written and oral communication skills, with a strong record of collaboration and innovation.
• Familiarity with biorthogonal conjugation techniques and next-generation site-specific conjugation platforms.

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:

• The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at the timeof this posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographic location, andwemayultimatelypaymore or less than the posted range. This range may bemodifiedin thefuture.

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.

• This job is eligible toparticipatein our short-term incentiveprograms.

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.The amount and availability of any bonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employeeremainsin the Company's sole andabsolutediscretion unless and until paid andmay bemodifiedat the Companys sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more, visithttps://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:

https://www.abbvie.com/join-us/reasonable-accommodations.html